abstract：:Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight disease mechanisms and therapeutic targets. We performed RNA sequencing of hypothalamus from individuals with Prader-Willi syndrome (PWS), a genetic obesity syndrome characterized by severe hyperphagia. We fou...

journal_title：Cell reports

authors： Bochukova EG,Lawler K,Croizier S,Keogh JM,Patel N,Strohbehn G,Lo KK,Humphrey J,Hokken-Koelega A,Damen L,Donze S,Bouret SG,Plagnol V,Farooqi IS

更新日期：2018-03-27 00:00:00

abstract：:Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid up...

journal_title：Cell reports

authors： van den Berg R,Kooijman S,Noordam R,Ramkisoensing A,Abreu-Vieira G,Tambyrajah LL,Dijk W,Ruppert P,Mol IM,Kramar B,Caputo R,Puig LS,de Ruiter EM,Kroon J,Hoekstra M,van der Sluis RJ,Meijer OC,Willems van Dijk K,van Kerk

更新日期：2018-03-27 00:00:00

abstract：:Phenylalanine-glycine-rich nucleoporins (FG-Nups) are intrinsically disordered proteins, constituting the selective barrier of the nuclear pore complex (NPC). Previous studies showed that nuclear transport receptors (NTRs) were found to interact with FG-Nups by forming an "archetypal-fuzzy" complex through the rapid f...

journal_title：Cell reports

authors： Tan PS,Aramburu IV,Mercadante D,Tyagi S,Chowdhury A,Spitz D,Shammas SL,Gräter F,Lemke EA

更新日期：2018-03-27 00:00:00

abstract：:Synaptic efficacy plays crucial roles in neuronal circuit operation and synaptic plasticity. Presynaptic determinants of synaptic efficacy are neurotransmitter content in synaptic vesicles and the number of vesicles undergoing exocytosis at a time. Bursts of presynaptic firings depress synaptic efficacy, mainly due to...

journal_title：Cell reports

authors： Yamashita M,Kawaguchi SY,Hori T,Takahashi T

更新日期：2018-03-20 00:00:00

abstract：:Large-scale, cooperative rearrangements underlie the functions of RNA in RNA-protein machines and gene regulation. To understand how such rearrangements are orchestrated, we used high-throughput chemical footprinting to dissect a seemingly concerted rearrangement in P5abc RNA, a paradigm of RNA folding studies. With m...

journal_title：Cell reports

authors： Gracia B,Al-Hashimi HM,Bisaria N,Das R,Herschlag D,Russell R

更新日期：2018-03-20 00:00:00

abstract：:The hippocampal formation is a brain structure essential for higher-order cognitive functions. It has a complex anatomical organization and cellular composition, and hippocampal subregions have different properties and functional roles. In this study, we used SWATH-MS to determine whether the proteomes of hippocampus ...

journal_title：Cell reports

authors： von Ziegler LM,Selevsek N,Tweedie-Cullen RY,Kremer E,Mansuy IM

更新日期：2018-03-20 00:00:00

abstract：:Reduced eukaryotic Initiation Factor 2 (eIF2)α phosphorylation (p-eIF2α) enhances protein synthesis, memory formation, and addiction-like behaviors. However, p-eIF2α has not been examined with regard to psychoactive cannabinoids and cross-sensitization. Here, we find that a cannabinoid receptor agonist (WIN 55,212-2 m...

journal_title：Cell reports

authors： Melas PA,Qvist JS,Deidda M,Upreti C,Wei YB,Sanna F,Fratta W,Scherma M,Fadda P,Kandel DB,Kandel ER

更新日期：2018-03-13 00:00:00

abstract：:In plants, the phytohormone auxin acts as a master regulator of developmental processes and environmental responses. The best characterized process in the auxin regulatory network occurs at the subcellular scale, wherein auxin mediates signal transduction into transcriptional programs by triggering the degradation of ...

journal_title：Cell reports

authors： Middleton AM,Dal Bosco C,Chlap P,Bensch R,Harz H,Ren F,Bergmann S,Wend S,Weber W,Hayashi KI,Zurbriggen MD,Uhl R,Ronneberger O,Palme K,Fleck C,Dovzhenko A

更新日期：2018-03-13 00:00:00

abstract：:The use of retinal organoids requires efficient differentiation from induced pluripotent stem cells (iPSCs). In this issue of Cell Reports, Wang et al. (2018) examine how the chromatin landscape after iPSC programming predicts their ability to differentiate into retinal tissue. ...

journal_title：Cell reports

authors： Roberts JM,Vetter ML

更新日期：2018-03-06 00:00:00

abstract：:Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modifications (epigenetic memory), of their cellular origins, and this may bias sub...

journal_title：Cell reports

authors： Wang L,Hiler D,Xu B,AlDiri I,Chen X,Zhou X,Griffiths L,Valentine M,Shirinifard A,Sablauer A,Thiagarajan S,Barabas ME,Zhang J,Johnson D,Frase S,Dyer MA

更新日期：2018-03-06 00:00:00

abstract：:Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe an...

journal_title：Cell reports

authors： Galimov ER,Pryor RE,Poole SE,Benedetto A,Pincus Z,Gems D

更新日期：2018-03-06 00:00:00

abstract：:Protein-coding genes undergo a wide array of regulatory interactions with factors that engage non-coding regions. Open reading frames (ORFs), in contrast, are thought to be constrained by coding function, precluding a major role in gene regulation. Here, we explore Piwi-interacting (pi)RNA-mediated transgene silencing...

journal_title：Cell reports

authors： Seth M,Shirayama M,Tang W,Shen EZ,Tu S,Lee HC,Weng Z,Mello CC

更新日期：2018-02-27 00:00:00

abstract：:The locomotion of C. elegans is balanced by excitatory and inhibitory neurotransmitter release at neuromuscular junctions. However, the molecular mechanisms that maintain the balance of synaptic transmission remain enigmatic. Here, we investigated the function of voltage-gated Ca2+ channels in triggering spontaneous r...

journal_title：Cell reports

authors： Liu H,Li L,Wang W,Gong J,Yang X,Hu Z

更新日期：2018-02-27 00:00:00

abstract：:Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to activation of PLCβ in almost all tumors and loss of BAP1 in the aggressive subset. We generated mice with melanocyte-specific expression of GNA11Q209L with and without h...

journal_title：Cell reports

authors： Moore AR,Ran L,Guan Y,Sher JJ,Hitchman TD,Zhang JQ,Hwang C,Walzak EG,Shoushtari AN,Monette S,Murali R,Wiesner T,Griewank KG,Chi P,Chen Y

更新日期：2018-02-27 00:00:00

abstract：:The diversity and complexity of the cancer transcriptome may contain transcripts unique to the tumor environment. Here, we report a LIN28B variant, LIN28B-TST, which is specifically expressed in hepatocellular carcinoma (HCC) and many other cancer types. Expression of LIN28B-TST is associated with significantly poor p...

journal_title：Cell reports

authors： Guo W,Hu Z,Bao Y,Li Y,Li S,Zheng Q,Lyu D,Chen D,Yu T,Li Y,Zhu X,Ding J,Zhao Y,He X,Huang S

更新日期：2018-02-20 00:00:00

abstract：:Trinucleotide repeat expansions involving CTG/CAG triplets are responsible for several neurodegenerative disorders, including myotonic dystrophy and Huntington's disease. Because expansions trigger the disease, contracting repeat length could be a possible approach to gene therapy for these disorders. Here, we show th...

journal_title：Cell reports

authors： Mosbach V,Poggi L,Viterbo D,Charpentier M,Richard GF

更新日期：2018-02-20 00:00:00

abstract：:Ethanol is the most common drug of abuse. It exerts its behavioral effects by acting on widespread neural circuits; however, its impact on glial cells is less understood. We show that Drosophila perineurial glia are critical for ethanol tolerance, a simple form of behavioral plasticity. The perineurial glia form the c...

journal_title：Cell reports

authors： Parkhurst SJ,Adhikari P,Navarrete JS,Legendre A,Manansala M,Wolf FW

更新日期：2018-02-13 00:00:00

abstract：:Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β cell (βIL-1Ra)-specific versus myeloid-cell (myeloIL-1Ra)-specific IL-1Ra knoc...

journal_title：Cell reports

authors： Böni-Schnetzler M,Häuselmann SP,Dalmas E,Meier DT,Thienel C,Traub S,Schulze F,Steiger L,Dror E,Martin P,Herrera PL,Gabay C,Donath MY

更新日期：2018-02-13 00:00:00

abstract：:We use super-resolution interferometric photoactivation and localization microscopy (iPALM) and a constrained photoactivatable fluorescent protein integrin fusion to measure the displacement of the head of integrin lymphocyte function-associated 1 (LFA-1) resulting from integrin conformational change on the cell surfa...

journal_title：Cell reports

authors： Moore TI,Aaron J,Chew TL,Springer TA

更新日期：2018-02-13 00:00:00

abstract：:The spindle assembly checkpoint (SAC) prevents premature segregation of chromosomes during mitosis. This process requires structural remodeling of MAD2 from O-MAD2 to C-MAD2 conformation. After the checkpoint is satisfied, C-MAD2 is reverted to O-MAD2 to allow anaphase-promoting complex/cyclosome (APC/C) to trigger an...

journal_title：Cell reports

authors： Ma HT,Poon RYC

更新日期：2018-02-06 00:00:00

abstract：:Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms largely unknown. We here revealed an intramolecular interaction of the TRPP3...

journal_title：Cell reports

authors： Zheng W,Cai R,Hofmann L,Nesin V,Hu Q,Long W,Fatehi M,Liu X,Hussein S,Kong T,Li J,Light PE,Tang J,Flockerzi V,Tsiokas L,Chen XZ

更新日期：2018-02-06 00:00:00

abstract：:Escape responses to threatening stimuli are vital for survival in all animal species. Larval zebrafish display fast escape responses when exposed to tactile, acoustic, and visual stimuli. However, their behavioral responses to chemosensory stimuli remain unknown. In this study, we found that carbon dioxide (CO2) induc...

journal_title：Cell reports

authors： Koide T,Yabuki Y,Yoshihara Y

更新日期：2018-01-30 00:00:00

abstract：:The timing of food intake and nutrient utilization is critical to health and regulated partly by the circadian clock. Increased amplitude of circadian oscillations and metabolic output has been found to improve health in diabetic and obesity mouse models. Here, we report a function for the circadian deadenylase Noctur...

journal_title：Cell reports

authors： Stubblefield JJ,Gao P,Kilaru G,Mukadam B,Terrien J,Green CB

更新日期：2018-01-30 00:00:00

abstract：:The root stem cell niche, which is composed of four mitotically inactive quiescent center (QC) cells and the surrounding actively divided stem cells in Arabidopsis, is critical for growth and root development. Here, we demonstrate that the Arabidopsis prohibitin protein PHB3 is required for the maintenance of root ste...

journal_title：Cell reports

authors： Kong X,Tian H,Yu Q,Zhang F,Wang R,Gao S,Xu W,Liu J,Shani E,Fu C,Zhou G,Zhang L,Zhang X,Ding Z

更新日期：2018-01-30 00:00:00

abstract：:Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through the rostral migratory stream (RMS). To generate neurons, V-SVZ NSCs need to activate and enter the ce...

journal_title：Cell reports

authors： Engler A,Rolando C,Giachino C,Saotome I,Erni A,Brien C,Zhang R,Zimber-Strobl U,Radtke F,Artavanis-Tsakonas S,Louvi A,Taylor V

更新日期：2018-01-23 00:00:00

abstract：:Characterization of the cardiac cellulome, the network of cells that form the heart, is essential for understanding cardiac development and normal organ function and for formulating precise therapeutic strategies to combat heart disease. Recent studies have reshaped our understanding of cardiac cellular composition an...

journal_title：Cell reports

authors： Skelly DA,Squiers GT,McLellan MA,Bolisetty MT,Robson P,Rosenthal NA,Pinto AR

更新日期：2018-01-16 00:00:00

abstract：:Recent studies have established important roles of de novo mutations (DNMs) in autism spectrum disorders (ASDs). Here, we analyze DNMs in 262 ASD probands of Japanese origin and confirm the "de novo paradigm" of ASDs across ethnicities. Based on this consistency, we combine the lists of damaging DNMs in our and publis...

journal_title：Cell reports

authors： Takata A,Miyake N,Tsurusaki Y,Fukai R,Miyatake S,Koshimizu E,Kushima I,Okada T,Morikawa M,Uno Y,Ishizuka K,Nakamura K,Tsujii M,Yoshikawa T,Toyota T,Okamoto N,Hiraki Y,Hashimoto R,Yasuda Y,Saitoh S,Ohashi K,Sakai

更新日期：2018-01-16 00:00:00

abstract：:The transcription factors (TFs) Nanog and Esrrb play important roles in embryonic stem cells (ESCs) and during primordial germ-cell (PGC) development. Esrrb is a positively regulated direct target of NANOG in ESCs that can substitute qualitatively for Nanog function in ESCs. Whether this functional substitution extend...

journal_title：Cell reports

authors： Zhang M,Leitch HG,Tang WWC,Festuccia N,Hall-Ponsele E,Nichols J,Surani MA,Smith A,Chambers I

更新日期：2018-01-09 00:00:00

abstract：:Dentate gyrus (DG) development requires specification of granule cell (GC) progenitors in the hippocampal neuroepithelium, as well as their proliferation and migration into the primordial DG. We identify the Plexin family members Plxna2 and Plxna4 as important regulators of DG development. Distribution of immature GCs...

journal_title：Cell reports

authors： Zhao XF,Kohen R,Parent R,Duan Y,Fisher GL,Korn MJ,Ji L,Wan G,Jin J,Püschel AW,Dolan DF,Parent JM,Corfas G,Murphy GG,Giger RJ

更新日期：2018-01-09 00:00:00

abstract：:Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, ...

journal_title：Cell reports

authors： Christoffersen C,Federspiel CK,Borup A,Christensen PM,Madsen AN,Heine M,Nielsen CH,Kjaer A,Holst B,Heeren J,Nielsen LB

更新日期：2018-01-02 00:00:00

abstract：:The large number of mutations identified across all cancers represents an untapped reservoir of targets that can be useful for therapeutic targeting if highly selective, mutation-specific reagents are available. We report here our attempt to generate such reagents: monoclonal antibodies against the most common R175H, ...

journal_title：Cell reports

authors： Hwang LA,Phang BH,Liew OW,Iqbal J,Koh XH,Koh XY,Othman R,Xue Y,Richards AM,Lane DP,Sabapathy K

更新日期：2018-01-02 00:00:00

abstract：:A mutation in the promoter of the Telomerase Reverse Transcriptase (TERT) gene is the most frequent noncoding mutation in cancer. The mutation drives unusual monoallelic expression of TERT, allowing immortalization. Here, we find that DNA methylation of the TERT CpG island (CGI) is also allele-specific in multiple can...

journal_title：Cell reports

authors： Stern JL,Paucek RD,Huang FW,Ghandi M,Nwumeh R,Costello JC,Cech TR

更新日期：2017-12-26 00:00:00

abstract：:Most tumor cells exhibit obligatory demands for essential amino acids (EAAs), but the regulatory mechanisms whereby tumor cells take up EAAs and EAAs promote malignant transformation remain to be determined. Here, we show that oncogenic MYC, solute carrier family (SLC) 7 member 5 (SLC7A5), and SLC43A1 constitute a fee...

journal_title：Cell reports

authors： Yue M,Jiang J,Gao P,Liu H,Qing G

更新日期：2017-12-26 00:00:00

abstract：:Pre-implantation embryo development is an intricate and precisely regulated process orchestrated by maternally inherited proteins and newly synthesized proteins following zygotic genome activation. Although genomic and transcriptomic studies have enriched our understanding of the genetic programs underlying this proce...

journal_title：Cell reports

authors： Gao Y,Liu X,Tang B,Li C,Kou Z,Li L,Liu W,Wu Y,Kou X,Li J,Zhao Y,Yin J,Wang H,Chen S,Liao L,Gao S

更新日期：2017-12-26 00:00:00

abstract：:DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How DNA methylation is regulated in developmental and cellular processes and ...

journal_title：Cell reports

authors： Veland N,Hardikar S,Zhong Y,Gayatri S,Dan J,Strahl BD,Rothbart SB,Bedford MT,Chen T

更新日期：2017-12-19 00:00:00

abstract：:The transcription factor hepatic leukemia factor (HLF) is strongly expressed in hematopoietic stem cells (HSCs) and is thought to influence both HSC self-renewal and leukemogenesis. However, the physiological role of HLF in hematopoiesis and HSC function is unclear. Here, we report that mice lacking Hlf are viable wit...

journal_title：Cell reports

authors： Komorowska K,Doyle A,Wahlestedt M,Subramaniam A,Debnath S,Chen J,Soneji S,Van Handel B,Mikkola HKA,Miharada K,Bryder D,Larsson J,Magnusson M

更新日期：2017-12-19 00:00:00

abstract：:ATP citrate lyase (ACL) plays a key role in regulating mitochondrial function, as well as glucose and lipid metabolism in skeletal muscle. We report here that ACL silencing impairs myoblast and satellite cell (SC) differentiation, and it is accompanied by a decrease in fast myosin heavy chain isoforms and MYOD. Conver...

journal_title：Cell reports

authors： Das S,Morvan F,Morozzi G,Jourde B,Minetti GC,Kahle P,Rivet H,Brebbia P,Toussaint G,Glass DJ,Fornaro M

更新日期：2017-12-12 00:00:00

abstract：:The central mechanism by which neurotensin (Nts) potentiates weight loss has remained elusive. We leveraged chemogenetics to reveal that Nts-expressing neurons of the lateral hypothalamic area (LHA) promote weight loss in mice by increasing volitional activity and restraining food intake. Intriguingly, these dual weig...

journal_title：Cell reports

authors： Woodworth HL,Beekly BG,Batchelor HM,Bugescu R,Perez-Bonilla P,Schroeder LE,Leinninger GM

更新日期：2017-12-12 00:00:00

abstract：:The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies and autoimmune diseases. G6 is an anti-idiotypic monoclonal Ab that selectively binds to IGHV1-6...

journal_title：Cell reports

authors： Avnir Y,Prachanronarong KL,Zhang Z,Hou S,Peterson EC,Sui J,Zayed H,Kurella VB,McGuire AT,Stamatatos L,Hilbert BJ,Bohn MF,Kowalik TF,Jensen JD,Finberg RW,Wang JP,Goodall M,Jefferis R,Zhu Q,Kurt Yilmaz N,Schiffer CA

更新日期：2017-12-12 00:00:00

abstract：:α-Actinins, a family of critical cytoskeletal actin-binding proteins that usually exist as anti-parallel dimers, play crucial roles in organizing the framework of the cytoskeleton through crosslinking the actin filaments, as well as in focal adhesion maturation. However, the molecular mechanisms underlying its functio...

journal_title：Cell reports

authors： Le S,Hu X,Yao M,Chen H,Yu M,Xu X,Nakazawa N,Margadant FM,Sheetz MP,Yan J

更新日期：2017-12-05 00:00:00